Trametinib

Trametinib 

En Español (Spanish Version)

(tra me' ti nib)

WHY is this medicine prescribed?

Trametinib is used to treat a certain type of melanoma (a type of skin cancer) that cannot be treated with surgery or that has spread to other parts of the body. Trametinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells.

HOW should this medicine be used?

Trametinib comes as a tablet to take by mouth. It is usually taken once a day on an empty stomach, at least 1 hour before or 2 hours after a meal. Take trametinib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take trametinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Do not stop taking trametinib without talking to your doctor.

Your doctor may adjust your dose of trametinib depending on your response to treatment and any side effects that you experience. Talk to your doctor about how you are feeling during your treatment.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Are there OTHER USES for this medicine?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What SPECIAL PRECAUTIONS should I follow?

Before taking trametinib,

  • tell your doctor and pharmacist if you are allergic to trametinib, any other medications, or any of the ingredients in trametinib tablets. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
  • tell your doctor if you have or have ever had lung disease or breathing problems; high blood pressure; heart, eye, liver, or kidney disease; or any other medical conditions.
  • tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while you are taking trametinib. You should use birth control to prevent pregnancy during your treatment with trametinib and for at least 4 months afterwards. Talk to your doctor about birth control methods that will work for you. If you become pregnant while taking trametinib, call your doctor. Trametinib may harm the fetus.
  • tell your doctor if you are breast-feeding or plan to breast-feed. You should not breast-feed while taking trametinib.

What SPECIAL DIETARY instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do IF I FORGET to take a dose?

Take the missed dose as soon as you remember it. However, if it is less than 12 hours until your next scheduled dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What SIDE EFFECTS can this medicine cause?

Trametinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • dry skin
  • dry eyes
  • sores on the mouth and tongue
  • dry mouth
  • stomach pain
  • nosebleed
  • diarrhea

Some side effects can be serious. If you experience any of these symptoms, stop taking trametinib and call your doctor immediately:

  • rapid, irregular, or pounding heartbeat
  • difficulty breathing
  • chest pain
  • swelling of the face, arms, legs, ankles, or feet
  • dizziness or lightheadedness
  • severe headache
  • shortness of breath

• cough

  • blurred vision
  • change in vision, including seeing halos (blurred outline around objects)
  • loss of vision
  • rash, red skin, or pimples

• itching

  • blisters, ulcers, or sores on the skin or nails
  • tingling, burning, redness, swelling, peeling or flaking, blisters, or sores on the palms of the hands or soles of the feet
  • decreased urination

Trametinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch ] or by phone [1-800-332-1088].

What should I know about STORAGE and DISPOSAL of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Do not place the tablets in other containers, such as daily or weekly pill boxes. Store it a refrigerator but do not freeze it. Do not remove the desiccant (small packet included with medication to absorb moisture) from your bottle. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

What should I do in case of OVERDOSE?

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

What OTHER INFORMATION should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests before and during your treatment to see if it is safe for you to receive trametinib and to check your body's response to trametinib. Your doctor will also check your blood pressure from time to time as needed.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand Names

  • Mekinist®

Medication Information

The information contained in this tool is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of this tool is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either expressed or implied. HCA makes no representation of warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, HCA makes no representation or warranties as to the opinions or other service or data you may access, download or use as a result of use of this tool. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. HCA does not assume any responsibility or risk for your use of this tool.

By searching using the form below, you hereby agree to the above conditions.

Go

If you are not certain how to spell the term, try using the first few letters to get a list of possible matches. (i.e. as for Aspirin)